Nicholas Van Panhuys PhD

Principal Investigator – Assistant Level

Email: nvanpanhuys (@) sidra.org
Phone: +974 4003 7559

  • Biography

    Dr. van Panhuys completed his BSc in Biochemistry and Molecular Biology, Cell and Developmental Biology at Victoria University (New Zealand). Following this, completed the Honors program in Molecular Biosciences at Victoria University. Before being awarded Rex and Betty Coker Post Graduate Scholarship to conduct his PhD studies at the Malaghan Institute for Medical Research (New Zealand) where he investigated the role of IL4 and STAT6 in protective immunity and T helper 2 immune responses.

    He was then awarded the NZ Foundation for Research Science and Technology post-doctoral fellowship award, to work as a visiting fellow at the National Institutes of Health (Bethesda, USA) in the Laboratory of Immunology with Dr. Ronald Germain. Consequently he was appointed as a research fellow in the Laboratory of Systems Biology at the NIAD, NIH. 

    Since July 2015, he has worked as a Principal Investigator and head of the Laboratory for Asthma and Allergic Disease at Sidra Medicine (Doha, Qatar).
  • Our Research and Approach

    In Qatar asthma and allergies represent a substantial health burden, especially during childhood with significant proportions of Qatari children suffering from eczema (22.5%), allergic rhinitis (30.5%) and asthma (19.8%). The main focus of Dr. van Panhuys’ research group is to study the development and progression of asthma and allergic diseases with a specific interest in neonatal and pediatric onset disease. Our major area of interest is in analyzing the cellular differentiation which controls the balance of cells in the immune system that are able to control disease by regulating inflammation and shutting down allergic responses, whilst at the same time trying to discern the molecular pathways which in certain individuals cause cells to escape from these regulatory controls leading to the initiation of disease. Dr. van Panhuys’ group aims to concentrate on studying the initiation and development of asthmatic and allergic responses through analysis of the cellular and molecular pathways responsible for disease progression, with the aim of developing novel therapies aimed at the prevention and treatment of allergic disease.
  • Lab Members

    Meritxell Espino Guarch, PhD
    Staff Scientist
    Email: mespinoguarch (@) sidra.org

    Tracy Augustine, PhD
    Postdoctoral Fellow
    Email: taugustine (@) sidra.org

    Mohammad Al-Aghbar, PhD
    Postdoctoral Fellow
    Email: malaghbar (@) sidra.org

    Sharadambal Sunder, PhD
    Research Specialist
    Email: ssunder2 (@) sidra.org

    Rana Nahas, MSc
    Research Specialist
    Email: rnahas (@) sidra.org

    Fariada Badri, MSc
    Research Coordinator
    Email: fbadri (@) sidra.org

SELECTED PUBLICATIONS(equal contribution, *corresponding):

  • Liarski VM, Sibley A, van Panhuys N, Ai J, Chang A, Kennedy D, Merolle M, Germain RN, Giger ML, Clark MR. Quantifying in situ adaptive immune cell cognate interactions in humans. Nat Immunol. (2019)
  • Abbirami Sathappan and Nicholas van Panhuys* Advances in In Vivo Imaging Techniques for the Visualization and Quantification of DC-T Cell Interactions. Journal of Immunobiology. (2017)
  • Van Panhuys, N*. Studying Dendritic Cell-T Cell Interactions Under In Vivo Conditions. Methods in Molecular Biology. (2017)
  • Veres T, Kopcsányi T, van Panhuys N, Gerner M, Liu Z, Rantakari P,Dunkel J, Miyasaka M, Jalkanen S, Germain R. CD4+ T-cell cytokine production within airway mucosal DC-T-cell clusters drives the local recruitment of myeloid effector cells in response to house dust mite allergen. Journal of Immunology. (2017)
  • Van Panhuys, N. TCR signal strength alters T-DC activation and interaction times and directs the outcome of differentiation. Frontiers in Immunology.(2016)
  • Liu Z, Gerner MY, Van Panhuys N, Levine AG, Rudensky AY, Germain RN. Nature. (2015)
  • Palmer DC, Guittard GC, Franco Z, Crompton JG, Eil RL, Patel SJ, Ji Y, Van Panhuys N, Klebanoff CA, Sukumar M, Clever D, Chichura A, Roychoudhuri R, Varma R, Wang E, Gattinoni L, Marincola FM, Balagopalan L, Samelson LE, Restifo NP. J Exp Med. (2015)
  • Chong WP, van Panhuys N, Chen J, Silver PB, Jittayasothorn Y, Mattapallil MJ, Germain RN, Caspi RR. J Exp Med. (2015)
  • Kolodin D, van Panhuys N, Li C, Magnuson AM, Cipolletta D, Miller CM, Wagers A, Germain RN, Benoist C, Mathis D. Antigen- and cytokine-driven accumulation of regulatory T cells in visceral adipose tissue of lean mice. Cell Metab. (2015)
  • van Panhuys N, Klauschen, F and Germain, R. T Cell Receptor-dependent Signal Intensity Dominantly Controls CD4+ T Cell Polarization In Vivo. Immunity. (2014)